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Genetic 'X-factor' may be behind Japan's Covid-19 success

Scientists have discovered a genetic advantage present in many ethnic Japanese that may be helping them to fight Covid-19 infections.

Charis Chang | News.com.au (http://news.com.au) (Fox News Australia) | 18 December 2021

https://www.news.com.au/world/coronavirus/health/genetic-xfactor-may-be-behind-japans-covid19-success/news-story/f363a4e8115d188acb74cd124f30e66e

Excerpt: Japan's success in driving down Covid-19 cases has mystified experts but scientists have now identified a genetic 'X-factor' among its population that may have helped the country turn its outbreak around.

Daily Covid cases in the country reached more than 23,000 on August 26 but have since fallen sharply to around 100 a day, with numbers remaining steady even as it heads into winter.
Scientists have struggled to explain the dramatic turnaround with some pointing to the influence of some 'X-factor'. One theory suggested the virus was driven to a "natural extinction" after several mutations led to it being unable to make copies of itself.

However, Japanese researchers from the Riken Institute in Tokyo have now found a possible genetic advantage that may explain the country's success, and published their findings in the British journal Communications Biology last week.
https://www.nature.com/articles/s42003-021-02885-6

Ethnic Japanese People are Predominately Genetically Chinese

The researchers found ethnic Japanese people are more likely to have a specific genetic feature related to white blood cells that could be helping the body to fight Covid-19.

"It could be considered an 'X-factor'," Riken immunotherapy laboratory team leader Professor Shin-ichiro Fujii told Nikkei Asia.

The protein located on the surface of white blood cells called HLA-A24, is common among some Asian groups, and is found in about 60 per cent of ethnic Japanese people, but is only present around 10-20 per cent of European and American populations.

HLA-A24 helps to activate the body's killer T cells and researchers believe that the protein helps T-cells to remember past infections caused by seasonal coronaviruses and to potentially respond when exposed to Covid-19.
Experiments showed that T-cells began to multiply when a peptide extracted from Covid-19's spike protein was added to blood samples containing HLA-A24. The samples also responded to peptides from other seasonal coronaviruses that typically cause colds.

Experts have also been amazed at the low death rates in the country, which has the world's fastest ageing population with almost 30 per cent aged 65 years or older.

"The number of deaths is really low," Institution for Future Welfare sociologist Professor Testuo Fukawa told the BBC.

"In 2020, Japanese life expectancy even increased. It's really very special. In other countries – including the United States, UK, Germany, France – all these countries' life expectancy decreased in 2020."

According to the Johns Hopkins University, the death rate in Japan from Covid-19 is 14.55 per 100,000. In the United States it is 244.49 per 100,000, although Australia is lower at 8.38 per 100,000.